Endocrine Abstracts

Introduction: Adrenocortical carcinomas (ACCs) are rare, frequently aggressive tumors. Pure virilizing carcinomas are infrequent, constituting 5 to 10% in most series.Clinical case: A 36-year-old female consults for 5 years evolution of amenorrhea associated with hirsutism attributed to polycistic ovary syndrome (PCOS) and treated with oral contraceptives during the previous 2 years. There was no other data on virilization, changes in body weight, hypert...

Introduction: The use of mitotane as ACC therapy is associated with multiple adverse effects including hypercholesterolemia due to increased levels of LDL cholesterol. There are no reported cases of severe hypertriglyceridemia (HTG).Clinical case: A 59-year-old male with a personal history of dyslipidemia phenotype IV and pulmonary emphysema, former smoker and drinker was diagnosed with non-functioning left-sided ACC. Left adrenalectomy + left nephrectom...

Introduction: The association of acromegaly and polyostotic fibrous dysplasia is a rare entity that presents more difficulties in achieving an effective treatment than classical acromegaly. Pregnancy is infrequent and carries a high risk when acromegaly is active.Clínical case: A 27 year old woman surgically treated for facial asymmetry, without café-au-lait spots or precocious puberty, was evaluated in 1992 after a normal pregnancy. In the bio...

Introduction: Cyclic Cushing’s Syndrome (CCS) is a rare disorder in which rhythmic fluctuations in the secretion of ACTH trigger cyclic variations in the production of adrenal steroids and an extremely variable clinical presentation. It should be considered when clinical hypercortisolism coexists with normal cortisol levels and a paradoxical response to the dexamethasone test, and when selective transsphenoidal adenomectomy fails after an uncomplicated intervention.<p...

Introduction: McCune Albright syndrome (MAS) is a rare, sporadic disease that affects the skin, skeleton and several endocrine systems, caused by an activating mutation in the GNAS gene that leads to endocrine cell hyperfunction and increased cell proliferation. The development of thyroid carcinoma in MAS is considered an uncommon event and, on the other hand, it is well established that acromegaly is associated with an increased prevalence of malignant tumors including thyroi...